AVE Data Coordination and Dissemination (DCD) Workstream

The Atlas of Variant Effects (AVE) Alliance aims to propel systematic and extensive measurement and analysis of the impact of genetic variants on functional elements of human, model organism and pathogen genomes, to further the understanding of genes, gene products and their regulation and empower the diagnosis and treatment of human disease.

The Data Coordination and Dissemination (DCD) workstream facilitates the registration of MAVE projects and dissemination of MAVE data, primarily by overseeing the growth and management of a MAVE database. This group is responsible for federating this database with other resources identified by data consumers (e.g. ClinGen, UniProt, PharmGKB). Members of this group:

• Engage with clinical and non-clinical data resources to enable MAVE data sharing
• Curate/organize MAVE data from literature into MaveDB and other resources
• Define and promote infrastructure for data deposition, coordination and dissemination
• Facilitate the registration of MAVE projects

All members are expected to follow the AVE Code of Conduct.

Please visit the AVE Alliance website for information on other workstreams.

Workstream Lead:

• Alan Rubin (WEHI)
• Contact: Lara Muffley

Workstream Members:

• Jeremy Arbesfeld (Ohio)
• Carol Bult (The Jackson Lab)
• Melissa Cline (UC Santa Cruz)
• Erwan Delage (Wellcome Sanger)
• Helen Firth (Newnham College, Cambridge)
• Julia Foreman (Wellcome Sanger)
• Sumaiya Iqbal (Broad Institute)
• Rachid Karam (Ambry Genetics)
• Shannon McNulty (UNC)
• Kevin Riehle (Baylor College of Medicine)
• Alex Wagner (GA4GH)

Previous members:

• Maria Martin (previous co-chair)(EMBL)
• Jack Nicoludis (Invitae)